1st Symposium on PK / PD - approaches to suppression of resistance to anti-infectives #

Organized by ISAP - International Society of Anti-infective Pharmacology

Munich, March 30th, 2007


Starts 11:00 o´clock, March 30th, 2007
Ends 19:00 o´clock, March 30th, 2007
"Bavarian Dinner" at 19:00 o´clock

Site: Munich, Eden Hotel Wolff (www.ehw.de)

Seats are limited. We encourage to register since only a few seats are left. If you did not register, and plan to come, please call the conference office if seats are still available. There may be cancellations.

Preliminary program
Address for inquiries and registration

Download Registration Form

Dear Symposium's participant,

thanks for registering to ISAP's first symposium on suppression of resistance. We have put together a fine program where all leading experts of ISAP and other societies will speak. We hope you will enjoy the symposium and gain a lot of new information. Realistically though, we have to be aware that there is not much truly solid science in this field and especially only for a very limited number of classes of agents.

But the symposium will clearly summarize what we know and need to know by summaries by the chairmen of the sessions as well as a final discussion. That discussion which brings together the leaders in the field will definitely be a highlight of the symposium to remember.

We also think that the hotel is of a size that creates a nice atmosphere. Personnel is friendly and we are not in room 356, somewhere in the catacombs of bloodless Mega - hotel.

We would be pleased if you also decided to stay for the "Bavarian Dinner" where we will have rich Bavarian food and hopefully many well-humored people. Some protagonists of a good sense of humor will certainly contribute with their "dinner speech".

Also think of participating in the ISAP - educational workshop the next morning: www.isap.org .

Have a safe trip and see you soon in enchanting Munich. Pray for good weather and you will love that city in the "Free state of Bavaria".

Fritz Sörgel
President of ISAP
International Society of Anti-infective Pharmacology
Nürnberg, Germany

Final program (as of March 30th, 2007)

Convenors: Fritz Sörgel, George Drusano, Hartmut Derendorf, Johan Mouton, Alisdair MacGowan

What we knew before.
What my presentation added ?
Speakers are encouraged to show in their final slide how their talk improved the knowledge on PK/PD of resistance development and its suppression.

At the end of each session chairmen will similarly summarize the essentials in the presentations and how the presentation improved our understanding on the PK/PD of resistance and its suppression.

The allocated time includes discussion that should be five minutes.

11:00 -12:00 NOON Introduction into PK/PD of anti-infectives - the essentials in 60 minutes
Hartmut Derendorf, Ph.D.; Ursula Theuretzbacher, Ph.D.
12:25 Introduction into the Symposium
Fritz Sörgel, Ph.D.
12:30 - 14:25 Session 1 - Basics of PK/PD and their importance for resistance issues
Chairmen: Mouton, Tam, Dudley
12:30 - 12:50 History and today's use of PK/PD of antiinfectives - academia's and industry's
William Craig, M.D.
12:50 - 13:20 This talk needed to be in this session since Alasdair has other obligations in the afternoon.
Using Dose Intensity to Help Suppress Resistant Mutant Subpopulation Amplification Alasdair MacGowan, M.D.
13:20 - 13:50 Models of Infection: In vitro vs. in vivo
Hartmut Derendorf. Ph.D.
13:50 - 14:20 Drug Penetration matters
Ursula Theuretzbacher, Ph.D.
14:20 - 14:25 Summary of chairmen
14.25 - 14:50 Break
14:50 - 16:50 Session 2 - Application of basic concepts I
Chairmen: Lipman, Tam, Mouton
14:50 - 15:20 Influence of duration of therapy on the emergence of resistance.
Johan Mouton, Ph.D.
15:20 - 15:50 Understanding the Impact of Therapy Duration on Resistant Mutant Subpopulation Amplification
George L. Drusano,MD
15:50 - 16:20 Antimicrobial drug resistance, regulation, and research (including in vitro vs. in vivo results)
Mike Dudley, Pharm.D.
16:20 - 16:50 MSW hypothesis tested in bacterial resistance studies using in vitro models.
Alexander Firsov, Ph.D.
16:50 - 17:10 Break
17:10 - 18:50 Session 3 - Application of basic concepts II
Chairmen: Drusano, Craig
17:10 - 17:40 Combination Chemotherapy - An Important Way to Suppress Resistance Emergence
Vincent Tam, Pharm.D.
17:40 - 18:10 Resistance in the intensive care unit - Conventional pharmacological thinking has failed us, can pharmacokinetics help?
Jeff Lipman, MD
18:10 - 18:40 Little known - here is my data and my vision
Resistance and resistance suppression issues of anti-virals and anti-tuberculosis drugs
George Drusano
18:40 - 18:50 Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antifungal activity of fluconazole and caspofungin against Candida albicans in vitro
Nicolas Venisse, Nicolas Grgoire, William Couet ( introduced by Hartmut Derendorf)
18:50 - 19:10 Summarizing the Symposium's results and General Discussion
Fritz Sörgel, George Drusano, Hartmut Derendorf, Johan Mouton,
General discussion with all speakers and symposium's participants
Summary of symposium, conclusions?
19:20 Bavarian Dinner

# Note: this is not a symposium of either ESCMID or ISC.

19:20 o´clock: "Bavarian dinner"
Dinner speaches - Historic and present concepts on development and prevention of resistance

Not all be taken seriously, time for good humor and self irony, e.g. of previous misconceptions in anti-infective pharmacology.

Presentation by Fritz Sörgel "Paul Ehrlich - Magic Bullets and the first description of resistance ("Arzneifestigkeit") to an antibiotic in 1904 - serious presentation.

Fee for dinner: 35 Euros (contains a maximum of half a liter of good Bavarian beer (Hacker-Pschorr); excessive use on own payment (--: )

Additional Information

Note that there will be no formal lunch.

The registration fee does include two vouchers for either coffee or mineral water at a reduced rate as well as a free sandwich. The hotel has a restaurant and the Main Train Station across the street has a lot of opportunities to get an inexpensive lunch.

The Eden Hotel Wolff is directly located at the main train station (Hauptbahnhof München). Please visit the homepage for details http://www.ehw.de/. The hotel has Internet access next to the meeting room and W-LAN. It is a smaller hotel with a nice atmosphere and friendly personnel.

The Bavarian Dinner will take place in the same hotel immediately after the meeting adjourns.

The dinner will be finished by approximately 21:30 o´clock. People can stay longer in this nice hotel to chat indefinitely at the bar. But some of us have to work the next morning.

Also note where you are chairman.


There will be the highly respected workshop by ISAP the next morning. Plan to attend and get further insights into the field of PK/PD of anti-infectives. (www.isap.org)



Fee: full positions: 100 Euros
ISAP -member: 50 Euros
Physician / scientist in training ( = 35 years) * : 50 Euros
Graduate students**: free
Dinner: 35 Euros

* Colleagues in training, born after 1 January 1972 (copy of passport obligatory)
** Students will need to provide proof (written certification by head of department)

Participants from not highly industrialized countries may request a waiver of fees.
Please write informally and give reasons.



please download the PDF and fax it to + 49 911 518 29 20; or mail to ibmp@osn.de . Only confirmed registrations are accepted. If you do not receive confirmation within one week please send again or ask.

All fees for congress registration and social events should be paid in EUR to

ISAP 07 Symp

clearly stating the participant's name and address. Payment can be effected either by bank transfer (free of charge) to

Account No. 16008113
Bank: Stadt- und Kreissparkasse Erlangen
Bank routing code: 763 500 00 ( within Germany )
IBAN: DE91 7635 0000 0016 0081 13
Swift Code : BYLADEM1ERH

Bank cheque: OK
No credit cards

If you want, you can also pay cash at the meeting's desk. But please inform us by eMail quickly what way you prefer. Please note that if you did not pay by March 27th ( money to arrive on the ISAP account shown on the homepage) we must collect the money from you cash on-site.
The account will be closed after March 27. Money that did not arrive by that day is considered "not received" - SORRY. You must then pay on-site to participate in the symposium.

Upon receipt of the correct registration fee, each participant will receive a confirmation of registration. Please bring this confirmation to the registration desk at the conference centre as proof of your registration.
On-site registrations will be accepted but cannot be guaranteed to receive all congress documents. Please arrive early if you wish to register on-site. The number of participants is limited to 60.

Please take all other information about Munich from the ECCMID -Homepage:

Hotel reservations cannot be made by ISAP.

Address for inquiries and registration:

Professor Fritz Sörgel
IBMP - Institute for Biomedical and
Pharmaceutical Research
Paul-Ehrlich-Strasse 19
90562 Nürnberg-Heroldsberg
Tel: +49 911 518 290
Fax: +49 911 518 2920
E-mail: ibmp@osn.de

All eMails or telefaxes MUST have this in the "subject area":

ISAP - Symposium, Munich 2007

If this is missing we will not open the mail or read the fax.